Kuczenski R, Segal D S
Department of Psychiatry, University of California, San Diego, La Jolla 92093-0603.
Synapse. 1992 Jun;11(2):164-9. doi: 10.1002/syn.890110210.
The response of extracellular norepinephrine to the acute administration of amphetamine was assessed, using dialysis, in prefrontal cortex and hippocampus in awake, behaving rats. Norepinephrine exhibited a pronounced and rapid dose- and time-dependent increase in response to 0.5 and 2.5 mg/kg amphetamine, which corresponded closely to the time course of the behavioral profile. These results are consistent in with a possible role for norepinephrine in the behavioral response to amphetamine.
在清醒、活动的大鼠中，利用透析法评估了前额叶皮质和海马体中细胞外去甲肾上腺素对急性给予苯丙胺的反应。去甲肾上腺素对0.5毫克/千克和2.5毫克/千克苯丙胺的反应呈现出显著且快速的剂量和时间依赖性增加，这与行为特征的时间进程密切对应。这些结果与去甲肾上腺素在对苯丙胺的行为反应中可能发挥的作用相一致。
