Haider M, Hatefi A, Ghandehari H
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, 21201, USA.
J Control Release. 2005 Dec 5;109(1-3):108-19. doi: 10.1016/j.jconrel.2005.09.018. Epub 2005 Nov 2.
A major challenge for successful cancer gene therapy is the development of safe and effective gene delivery vectors. Gene delivery vectors can be viral or nonviral. Among nonviral vectors various polymeric vectors have shown potential in gene delivery. However, much work needs to be done in order to correlate polymer structure with gene release at the target site and transfection efficiency. This article is a brief introduction into cancer gene therapy, barriers and methods for gene transfer with emphasis on the applications of recombinant polymers for cancer gene therapy.
成功进行癌症基因治疗的一个主要挑战是开发安全有效的基因传递载体。基因传递载体可以是病毒载体或非病毒载体。在非病毒载体中，各种聚合物载体已在基因传递方面显示出潜力。然而，为了将聚合物结构与靶位点的基因释放及转染效率相关联，仍有许多工作要做。本文简要介绍了癌症基因治疗、基因转移的障碍和方法，重点是重组聚合物在癌症基因治疗中的应用。
