Gu Keli, Bi Lanrong, Zhao Ming, Wang Chao, Dolan Cheryl, Kao Michael C, Tok Jeffrey B-H, Peng Shiqi
College of Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing, PR China.
Bioorg Med Chem. 2006 Mar 1;14(5):1339-47. doi: 10.1016/j.bmc.2005.09.068. Epub 2005 Nov 2.
A class of 5-trifluoroacetylamino-1,3-dioxacycloalkanes, 5-benzoylamino-1,3-dioxacycloalkanes, and 5-amino-1,3-dioxacycloalkane compounds were stereoselectively synthesized as potential anti-inflammatory drug candidates. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model, from which multiple compounds possessing anti-inflammatory properties which surpass aspirin were identified; these compounds were then compared to establish structure-activity relationships.
