Swarup Jyothi, Balkundi Dhruv, Sobchak Brozanski Beverly, Roberts James Michael, Yanowitz Toby Debra
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
Hypertens Pregnancy. 2005;24(3):223-34. doi: 10.1080/10641950500281209.
To test the hypothesis that very low birth infants born to mothers with preeclampsia have higher blood pressure over the first week of life than infants whose mothers did not have preeclampsia.
Infants born at<1,350 g who survived at least one week were stratified by gestational age ( <or= 28 weeks and >or= 29 completed weeks) and grouped by the presence or absence of preeclampsia. Highest and lowest systolic and mean and diastolic blood pressures were recorded for each of the first seven days of life. Serial blood pressures were analyzed by repeated measures ANOVA: The presence of hypertension (defined as >or= 3 days with the highest systolic blood pressure>90th percentile for gestational age stratum and day-specific range) was analyzed by binary logistic regression.
Infants >or= 29 weeks gestational age born to mothers with preeclampsia had higher blood pressures than did controls. Infants <or= 28 weeks gestational age born to preeclamptic and non-preeclamptic mothers had similar blood pressures. In the combined cohort, hypertension was not more prevalent among infants born to women with preeclampsia.
Preeclampsia is associated with higher blood pressure in very low birth weight neonates who are >or= 29 weeks gestation. The long-term significance of this finding is not known.
检验以下假设，即子痫前期母亲所生的极低体重儿在出生后第一周的血压高于其母亲未患子痫前期的婴儿。
对出生体重<1350克且存活至少一周的婴儿，按胎龄（≤28周和≥29足周）分层，并根据是否患有子痫前期分组。记录出生后前七天每天的最高和最低收缩压、平均血压及舒张压。采用重复测量方差分析对系列血压进行分析：通过二元逻辑回归分析高血压（定义为收缩压最高值≥3天超过胎龄层第90百分位数及特定日范围）的存在情况。
子痫前期母亲所生胎龄≥29周的婴儿血压高于对照组。子痫前期和非子痫前期母亲所生胎龄≤28周的婴儿血压相似。在合并队列中，子痫前期女性所生婴儿中高血压的患病率并不更高。
子痫前期与胎龄≥29周的极低出生体重新生儿血压升高有关。这一发现的长期意义尚不清楚。
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