一项关于长效皮质类固醇治疗白塞病的双盲试验。
A double-blind trial of depot corticosteroids in Behçet's syndrome.
作者信息
Mat C, Yurdakul S, Uysal S, Gogus F, Ozyazgan Y, Uysal O, Fresko I, Yazici H
机构信息
Department of Dermatology, Bahçet's Syndrome Research Centre, Cerrahpasa Medical Faculty , Univerisity of Istanbul, Turkey.
出版信息
Rheumatology (Oxford). 2006 Mar;45(3):348-52. doi: 10.1093/rheumatology/kei165. Epub 2005 Nov 1.
OBJECTIVES
Corticosteroids are widely used in Behçet's syndrome despite the absence of controlled studies. We assessed the effect of depot corticosteroids primarily for genital ulcers and secondarily for the other mucocutaneous manifestations of Behçet's syndrome.
METHODS
We randomized 86 patients who had active disease with genital ulcers to receive either intramuscular corticosteroid injections (40 mg methylprednisolone acetate) or placebo every 3 weeks for 27 weeks.
RESULTS
Seventy-six patients (88%) completed the treatment. There were no significant differences in the mean number of genital and oral ulcers, or folliculitis between groups. The mean number of erythema nodosum lesions was less in the corticosteroid group as a whole (P = 0.0046); subgroup analyses revealed that this was significant for females (P = 0.0148) but not for males (P = 0.1).
CONCLUSION
Low-dose depot corticosteroids did not have any beneficial effect on genital ulcers. However, it was useful in controlling erythema nodosum lesions, especially among the females.
目的
尽管缺乏对照研究，但皮质类固醇在白塞病中仍被广泛使用。我们评估了长效皮质类固醇对生殖器溃疡的疗效，其次评估了其对白塞病其他黏膜皮肤表现的疗效。
方法
我们将86例患有活动性生殖器溃疡疾病的患者随机分组，每3周分别接受肌肉注射皮质类固醇（40mg醋酸甲泼尼龙）或安慰剂，共治疗27周。
结果
76例患者（88%）完成了治疗。两组之间生殖器和口腔溃疡的平均数量或毛囊炎无显著差异。皮质类固醇组结节性红斑病变的平均数量总体较少（P = 0.0046）；亚组分析显示，这在女性中具有显著性（P = 0.0148），而在男性中则无显著性（P = 0.1）。
结论
低剂量长效皮质类固醇对生殖器溃疡没有任何有益作用。然而，它有助于控制结节性红斑病变，尤其是在女性中。
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