抗TNF生物制剂对白塞病患者葡萄膜炎严重程度的影响：系统评价与Meta分析。
Effects of anti-TNF biologic drugs on uveitis severity in Behçet patients: systematic review and Meta-analysis.
作者信息
Abolhasani Somayeh, Khabbazi Alireza, Hosseini Foroogh, Gholizadeh-Ghaleh Aziz Shiva, Alipour Shahriar
机构信息
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia 5756115111, Iran.
Student Research Committee, Urmia University of Medical Sciences, Urmia 5756115111, Iran.
出版信息
Int J Ophthalmol. 2022 May 18;15(5):813-819. doi: 10.18240/ijo.2022.05.19. eCollection 2022.
AIM
To investigate effects of anti-TNF biologic drugs on uveitis severity (comparing visual acuity logMAR levels) in Behçet patients.
METHODS
Three databases PubMed, Scopus, and the Web of Science were searched for qualified papers focusing on the anti-TNF-α factors treatment in Behçet's disease (BD)-associated uveitis. Studies that were designed pre and post anti-TNF drug treatment, were selected. After determining the search strategy for this study, the relevant data were extracted.
RESULTS
The initial search was performed in the target databases and a total of about 1458 articles were found. Fifteen articles were selected for systematic review and only 12 of them had inclusion criteria for Meta-analysis (with visual acuity data). The mean dose of prednisolone before and after biological treatments was reported in 5 studies (28.56 and 7.56 mg/kg, respectively). Also, the preliminary results indicate a significant reduction in visual acuity logMAR levels (MD=-1.5 IU/L, 95%CI: -2.1, -0.01).
CONCLUSION
Biological drugs significantly reduce the dose of prednisolone and affect visual acuity values.
目的
研究抗TNF生物药物对白塞病患者葡萄膜炎严重程度的影响（比较最小分辨角对数视力水平）。
方法
检索三个数据库（PubMed、Scopus和科学网），查找关注抗TNF-α因子治疗白塞病（BD）相关性葡萄膜炎的合格论文。选择在抗TNF药物治疗前后设计的研究。确定本研究的检索策略后，提取相关数据。
结果
在目标数据库中进行了初步检索，共找到约1458篇文章。选择了15篇文章进行系统评价，其中只有12篇符合Meta分析的纳入标准（有视力数据）。5项研究报告了生物治疗前后泼尼松龙的平均剂量（分别为28.56和7.56mg/kg）。此外，初步结果表明最小分辨角对数视力水平显著降低（MD=-1.5IU/L，95%CI：-2.1，-0.01）。
结论
生物药物显著降低泼尼松龙剂量并影响视力值。
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