Chilson Crystal N, Brown Sherrill J
Skaggs School of Pharmacy, University of Montana, Missoula, USA.
Ann Pharmacother. 2005 Dec;39(12):2081-5. doi: 10.1345/aph.1G239. Epub 2005 Nov 1.
To evaluate the role of botulinum toxin type A in the prophylaxis of migraine headaches.
MEDLINE (1966-July 2005), Iowa Drug Information Service (1966-July 2005), and International Pharmaceutical Abstracts (1970-July 2005) searches were performed. Key search terms included botulinum and migraine.
Patients who received botulinum toxin type A injections for treatment of hyperfunctional facial lines also experienced relief of migraine symptoms, leading to further investigation. Four clinical trials and 2 retrospective chart reviews evaluating the use of botulinum toxin type A injections for the prophylactic treatment of migraines are discussed. Limitations of these trials include problems with blinding, use of different injection sites, and inconsistent dosing.
The results of 3 double-blind, placebo-controlled trials, 2 retrospective chart reviews, and an open-label study indicate that botulinum toxin type A may be a safe and efficacious prophylactic treatment for migraine headaches.
评估A型肉毒毒素在偏头痛预防中的作用。
进行了MEDLINE（1966年 - 2005年7月）、爱荷华药物信息服务（1966年 - 2005年7月）以及国际药学文摘（1970年 - 2005年7月）的检索。关键检索词包括肉毒杆菌和偏头痛。
接受A型肉毒毒素注射以治疗面部功能亢进性皱纹的患者，其偏头痛症状也得到缓解，从而引发了进一步研究。讨论了四项评估A型肉毒毒素注射用于偏头痛预防性治疗的临床试验和两项回顾性病历审查。这些试验的局限性包括盲法问题、不同注射部位的使用以及剂量不一致。
三项双盲、安慰剂对照试验、两项回顾性病历审查以及一项开放标签研究的结果表明，A型肉毒毒素可能是一种安全有效的偏头痛预防性治疗方法。
