Morton Rosemary J, Guy Matthew J, Marshall Craig A, Clarke Elizabeth A, Hinton Paul J
Department of Nuclear Medicine, Royal Surrey County Hospital, Guildford, Surrey, UK.
Nucl Med Commun. 2005 Dec;26(12):1131-7. doi: 10.1097/00006231-200512000-00014.
To acquire data from a 123I filled Alderson phantom on different gamma cameras types and compare the relative uptake results from processing using the QuantiSPECT program (GE Healthcare).
A DaTSCAN phantom was filled using the standard protocol and imaged on seven different gamma camera types and on two identical cameras of the same type. The standard GE Healthcare protocols for the given cameras were used. Aliquots of the striatum and brain background were counted in a gamma counter to determine variations in filling concentration. All the raw DaTSCAN SPECT data was imported into QuantiSPECT and processed by the three different algorithms (two box, three box and crescent) to determine the relative uptake in the striatum. Inter-operater and intra-operator variation was also determined.
The 10% variation in filling concentration found across the sites was compensated for in the final results. There was a 5-15% variation between cameras depending on the processing algorithm used. There was an intra-operator variation of between 5 and 12% which reflected the proportion of operator intervention within the processing method. There was no statistical variation between operators.
The transfer of a DaTSCAN database between camera types is feasible, but ideally all data would be acquired on a single camera type and phantom data used to normalize the database accordingly.
从一个填充了123I的阿尔德森体模获取不同型号伽马相机的数据，并比较使用QuantiSPECT程序（通用电气医疗集团）处理后的相对摄取结果。
使用标准方案填充DaTSCAN体模，并在七种不同型号的伽马相机以及两台相同型号的同一相机上进行成像。使用了通用电气医疗集团针对给定相机的标准方案。在伽马计数器中对纹状体和脑本底的等分试样进行计数，以确定填充浓度的变化。将所有原始DaTSCAN SPECT数据导入QuantiSPECT，并通过三种不同算法（两框、三框和月牙形）进行处理，以确定纹状体中的相对摄取。还确定了不同操作人员之间以及同一操作人员内部的差异。
在最终结果中补偿了各部位发现的10%的填充浓度变化。根据所使用的处理算法，相机之间存在5%至15%的变化。同一操作人员内部的差异在5%至12%之间，这反映了处理方法中操作人员干预的比例。不同操作人员之间没有统计学差异。
在不同型号相机之间转移DaTSCAN数据库是可行的，但理想情况下，所有数据都应在单一型号相机上获取，并相应地使用体模数据对数据库进行标准化。
