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多支冠状动脉疾病患者的完全血运重建策略(1985 - 1986年美国国立心肺血液研究所经皮冠状动脉腔内血管成形术登记报告)

Strategy of complete revascularization in patients with multivessel coronary artery disease (a report from the 1985-1986 NHLBI PTCA Registry).

作者信息

Bourassa M G, Holubkov R, Yeh W, Detre K M

机构信息

Research Center, Montreal Heart Institute, Quebec, Canada.

出版信息

Am J Cardiol. 1992 Jul 15;70(2):174-8. doi: 10.1016/0002-9149(92)91271-5.

Abstract

Percutaneous transluminal coronary angioplasty (PTCA) is increasingly performed in patients with multivessel coronary artery disease (CAD) despite reports showing relatively low rates of complete revascularization and poorer long-term prognosis for patients with significant residual narrowings. Reasons for incomplete revascularization were assessed in 618 patients with multivessel CAD in the 1985-1986 National Heart, Lung, and Blood Institute (NHLBI) PTCA Registry. The PTCA operator was asked to describe the treatment plan and outcome for each of the 1,942 significant lesions (greater than or equal to 50% luminal diameter stenosis) in the Registry patients. Although all significant narrowings were considered amenable to balloon angioplasty in 77% of patients, complete correction was intended only for 34% of them. It was attempted in 28% and successful in 19%. Only 63% of total occlusions were considered amenable to PTCA and only 54% of those attempted were successfully dilated. PTCA was intended for 38% with 50 to 69% stenoses versus 80% with 70 to 89% stenoses and for greater than 85% with narrowings greater than or equal to 90%. Dilatation in narrowings of the left circumflex and left anterior descending artery systems was intended less frequently than in lesions of the right coronary artery. Finally, there was wide variability in operator strategy among the different Registry sites.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

经皮腔内冠状动脉成形术(PTCA)越来越多地应用于多支冠状动脉疾病(CAD)患者,尽管有报告显示完全血运重建率相对较低,且有明显残余狭窄的患者长期预后较差。在1985 - 1986年美国国立心肺血液研究所(NHLBI)PTCA注册研究中,对618例多支CAD患者血运重建不完全的原因进行了评估。要求PTCA手术医生描述注册研究患者中1942处明显病变(管腔直径狭窄大于或等于50%)的治疗方案及结果。尽管77%的患者中所有明显狭窄都被认为适合球囊血管成形术,但仅34%的患者旨在进行完全矫正。28%的患者尝试了完全矫正,其中19%成功。仅63%的完全闭塞被认为适合PTCA,且尝试的病例中仅54%成功扩张。对于50%至69%狭窄的病变,PTCA治疗的意向率为38%,而对于70%至89%狭窄的病变,意向率为80%,对于狭窄大于或等于90%且狭窄率大于85%的病变,意向率更高。左旋支和左前降支系统狭窄的扩张意向率低于右冠状动脉病变。最后,不同注册研究地点的手术医生策略存在很大差异。(摘要截选至250字)

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