Zhou Casey Chun, Huang Xiaomei, Ford Kelley L, Hollis L Steven
J Antibiot (Tokyo). 2005 Aug;58(8):539-44. doi: 10.1038/ja.2005.75.
In the manufacturing process for Biaxin (clarithromycin), erythromycin-A oxime, an intermediate, is obtained in high yield, when erythromycin-A is treated with hydroxylamine/isopropyl alcohol in the presence of acetic acid. An unusual impurity, the desosamine hydrazinium salt, is generated in this step of the synthetic pathway, and has been isolated and characterized by using one and two-dimensional NMR spectroscopy in conjunction with MS and EDS.
在制备百炎净（克拉霉素）的过程中，当红霉素 -A在乙酸存在下用羟胺/异丙醇处理时，中间体红霉素 -A肟可高产率获得。在该合成途径的这一步骤中会产生一种不寻常的杂质，去氧氨基糖肼盐，并且已经通过一维和二维核磁共振光谱结合质谱和能谱对其进行了分离和表征。
