[汉族儿童双胞胎身体生长指标的遗传效应]

[Genetic effects on physical growth items of child twins in Han nationality].

作者信息

Li Yu-ling, Ji Cheng-ye, Lu Shun-hua, Suo Li-ya, Bai Jin-lan, Yang Xiao-min, Wen Xiao-yan, Wang Wei

机构信息

Institute of Child and Adolescent Health, Peking University, Beijng 100083, China.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 2005 Sep;39(5):345-7.

PMID:16266548

Abstract

OBJECTIVE

To analyse the heritabilities of physical growth items of body and its related factors.

METHODS

An 116 twin pairs of Han nationality, 67 monozygotic (MZ) and 49 like-sex dizygotic (DZ) aged 6 to 12 years, were investigated from June to October in 2004. The measurements included height, weight, sitting height, chest circumference, biacromial breadth and biiliac breadth, and BMI index calculated by the former two measurements. The heritabilities were estimated by using intraclass correlation coefficient method from the adjusted data for age.

RESULTS

The intraclass correlation coefficient was greater in the MZ twins than in the DZ twins. The estimated heritabilities of height, weight, BMI, sitting height, chest circumference, biacromial breadth and biiliac breadth were 0.89, 0.88, 0.73, 0.87, 0.78, 0.78, 0.73 in boys and 0.87, 0.74, 0.72, 0.86, 0.62, 0.56, 0.59 in girls adjusted for age. Therefore, there were no sex difference for the heritabilities of height, sitting height and BMI, but the male heritabilities of weight, chest circumference, biacromial breadth and biiliac breadth were higher than the female's respectively.

CONCLUSION

Physical growth items should be mainly determined by the genetic factors. There are sex differences for the heritabilities of weight, chest circumference, biacromial breadth and biiliac breadth, i.e., the girls might be affected more easily by environmental factors than the boys in these items.

摘要

目的

分析身体生长指标的遗传力及其相关因素。

方法

2004年6月至10月，对116对6至12岁的汉族双胞胎进行调查，其中67对同卵双胞胎（MZ），49对同性异卵双胞胎（DZ）。测量指标包括身高、体重、坐高、胸围、肩宽和髂嵴间宽，并通过身高和体重计算BMI指数。采用组内相关系数法从年龄校正数据中估计遗传力。

结果

同卵双胞胎的组内相关系数大于异卵双胞胎。校正年龄后，男孩身高、体重、BMI、坐高、胸围、肩宽和髂嵴间宽的估计遗传力分别为0.89、0.88、0.73、0.87、0.78、0.78、0.73，女孩分别为0.87、0.74、0.72、0.86、0.62、0.56、0.59。因此，身高、坐高和BMI的遗传力无性别差异，但男孩体重、胸围、肩宽和髂嵴间宽的遗传力分别高于女孩。