Ketai Loren, Harkins Michelle, Fiato Karen-Lynn, Iwamoto Gary K
Department of Radiology, University of New Mexico, Albuquerque, New Mexico 87131, USA.
J Asthma. 2005 Oct;42(8):667-71. doi: 10.1080/02770900500264978.
To assess whether bronchial wall thickening during asthma exacerbations is due to active inflammation in severe asthmatics, we measured bronchial wall thickness and exhaled nitric oxide (FeNO) following treatment. Nine asthmatics were compared with seven controls with high-resolution computed tomography, spirometry, and FeNO measurements. The asthmatic bronchial wall area percent and FeNO was greater than controls. Following treatment, the FEV1 markedly improved, FeNO decreased modestly, and bronchial wall area percent did not change significantly. Bronchial wall thickening persisted after treatment of acute asthma exacerbation despite improvement in spirometry and decline in FeNO, possibly due to chronic airway remodeling.
为评估哮喘加重期支气管壁增厚是否因重度哮喘患者的活动性炎症所致，我们在治疗后测量了支气管壁厚度和呼出一氧化氮（FeNO）。将9名哮喘患者与7名对照者进行高分辨率计算机断层扫描、肺功能测定和FeNO测量比较。哮喘患者的支气管壁面积百分比和FeNO高于对照者。治疗后，第一秒用力呼气容积（FEV1）显著改善，FeNO略有下降，支气管壁面积百分比无显著变化。尽管肺功能测定有所改善且FeNO下降，但急性哮喘加重期治疗后支气管壁增厚仍持续存在，这可能是由于慢性气道重塑所致。
