蛋白酶和氧化剂作为慢性阻塞性肺疾病治疗的靶点。
Proteinases and oxidants as targets in the treatment of chronic obstructive pulmonary disease.
作者信息
Owen Caroline A
机构信息
Division of Pulmonary and Critical Care Medicine, 905 Thorn Building, Brigham and Women's Hospital, Boston, MA 02115, USA.
出版信息
Proc Am Thorac Soc. 2005;2(4):373-85; discussion 394-5. doi: 10.1513/pats.200504-029SR.
Abstract
There is now compelling evidence that proteinases and oxidative stress play pathogenetic roles in the following pathologies in chronic obstructive pulmonary disease: airspace enlargement; chronic inflammation in the airways, lung interstitium, and alveolar space; and mucus hypersecretion in the large airways. Proteinases and oxidants may also contribute to remodeling processes in the small airways. In addition, data are emerging that show interactions between classes of proteinases and between proteinases and oxidants, which amplify lung inflammation and injury in chronic obstructive pulmonary disease. This review discusses the biologic roles of proteinases and oxidants, their roles in the pathogenesis of chronic obstructive pulmonary disease, and their potential as targets for therapy.
摘要
目前有确凿证据表明，蛋白酶和氧化应激在慢性阻塞性肺疾病的以下病理过程中发挥致病作用：气腔扩大；气道、肺间质和肺泡腔的慢性炎症；以及大气道黏液分泌过多。蛋白酶和氧化剂也可能促成小气道的重塑过程。此外，越来越多的数据表明，不同类别的蛋白酶之间以及蛋白酶与氧化剂之间存在相互作用，这会加剧慢性阻塞性肺疾病中的肺部炎症和损伤。本文综述了蛋白酶和氧化剂的生物学作用、它们在慢性阻塞性肺疾病发病机制中的作用以及作为治疗靶点的潜力。
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