Gallegos-Torres J, Flores-Mercado F
Centro Gineco-Pediatrico Privado, Sinaloa, Mexico.
J Int Med Res. 1975;3(3):194-201. doi: 10.1177/030006057500300309.
The drug combination including isoxsuprine 10 mg, acetaminophen 250 mg and caffeine 30 mg was administered to 80 patients divided into two groups, 40 with premenstrual tension and 40 with clinically diagnosed primary dysmenorrhoea. The study was carried out by the double-blind method and the patients were distributed at random. The results obtained show an excellent or very good response in 95% of cases of premenstrual tension and in 92.5% of cases of dysmenorrhoea. When the overall effectiveness of the compound in both conditions is considered, we find it to be 93.75%. A general discussion of the findings is presented in relation to age, civil status, time of appearance of dysmenorrhoea, nature of pain, accompanying symptoms, previous treatment, other non-drug therapies, results obtained, time within which symptoms were alleviated, total dose of the drug and side-effects. It is concluded that the orally-administered therapeutic combination is effective in both dysmenorrhoea and premenstrual tension.
将含有10毫克异克舒令、250毫克对乙酰氨基酚和30毫克咖啡因的药物组合给予80名患者，这些患者被分为两组，40名患有经前紧张症，40名患有临床诊断的原发性痛经。该研究采用双盲法进行，患者随机分配。所得结果显示，95%的经前紧张症病例和92.5%的痛经病例有极佳或非常好的反应。当考虑该化合物在两种病症中的总体有效性时，我们发现其为93.75%。针对年龄、婚姻状况、痛经出现时间、疼痛性质、伴随症状、既往治疗、其他非药物疗法、所得结果、症状缓解时间、药物总剂量和副作用等方面，对研究结果进行了全面讨论。得出的结论是，口服治疗组合对痛经和经前紧张症均有效。
