Rubin A, Winter L
J Int Med Res. 1984;12(6):338-45. doi: 10.1177/030006058401200604.
In a double-blind, randomized controlled trial among 500 post-partum patients experiencing moderate to severe pain, a single oral dose of an aspirin/caffeine combination (800 mg aspirin, 65 mg caffeine) provided significantly more pain relief at 2 hours than did a higher dose of an acetaminophen/aspirin combination (648 mg acetaminophen, 648 mg aspirin) and a higher dose of acetaminophen alone (1000 mg acetaminophen). At 3 and 4 hours, the acetaminophen/aspirin combination as well as the aspirin/caffeine combination were significantly superior to acetaminophen alone. At all times, all three drugs were significantly superior to placebo. There were no clinically significant adverse reactions. These results provide evidence of a potentiating effect of caffeine on aspirin's analgesic potency.
在一项针对500名有中度至重度疼痛的产后患者的双盲随机对照试验中，单次口服一剂阿司匹林/咖啡因组合（800毫克阿司匹林，65毫克咖啡因）在2小时时提供的疼痛缓解效果明显优于较高剂量的对乙酰氨基酚/阿司匹林组合（648毫克对乙酰氨基酚，648毫克阿司匹林）和较高剂量的单独对乙酰氨基酚（1000毫克对乙酰氨基酚）。在3小时和4小时时，对乙酰氨基酚/阿司匹林组合以及阿司匹林/咖啡因组合明显优于单独使用对乙酰氨基酚。在所有时间点，这三种药物都明显优于安慰剂。没有临床上显著的不良反应。这些结果提供了咖啡因增强阿司匹林镇痛效力的证据。
