通过亲电环化合成异恶唑。
Synthesis of isoxazoles via electrophilic cyclization.
作者信息
Waldo Jesse P, Larock Richard C
机构信息
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
出版信息
Org Lett. 2005 Nov 10;7(23):5203-5. doi: 10.1021/ol052027z.
PMID:16268538
Abstract
[reaction: see text] A variety of 3,5-disubstituted 4-halo(seleno)isoxazoles are readily prepared in good to excellent yields under mild reaction conditions by the reaction of 2-alkyn-1-one O-methyl oximes with ICl, I2, Br2, or PhSeBr.
摘要
[反应：见正文] 通过2-炔-1-酮O-甲基肟与ICl、I₂、Br₂或PhSeBr反应，在温和的反应条件下，各种3,5-二取代4-卤（硒）异恶唑能以良好至优异的产率轻松制备出来。
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