通过N-（2-炔基）苯胺的亲电环化反应合成取代喹啉。
Synthesis of substituted quinolines by electrophilic cyclization of N-(2-alkynyl)anilines.
作者信息
Zhang Xiaoxia, Campo Marino A, Yao Tuanli, Larock Richard C
机构信息
Department of Chemistry, Iowa State University, Ames, IA 50011, USA.
出版信息
Org Lett. 2005 Mar 3;7(5):763-6. doi: 10.1021/ol0476218.
PMID:15727435
Abstract
Quinolines substituted in the 3-position by an iodo or phenylseleno group are readily prepared in good to excellent yields by the reaction of propargylic anilines with appropriate electrophiles under mild reaction conditions. [reaction: see text]
摘要
在温和的反应条件下，通过炔丙基苯胺与适当的亲电试剂反应，可轻松制备在3位被碘或苯硒基取代的喹啉，产率良好至优异。[反应：见正文]
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