通过皮克特-施彭格勒环化反应制备取代的嘧啶并[4,5-b]-1,4-苯并恶嗪、苯并噻嗪和二氮杂卓。
Preparation of substituted pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines via a Pictet-Spengler cyclization.
作者信息
Duncton Matthew A J, Smith Leon M, Burdzovic-Wizeman Sabina, Burns Aaron, Liu Hu, Mao Yunyu, Wong Wai C, Kiselyov Alexander S
机构信息
Department of Chemistry, ImClone Systems, 710 Parkside Avenue, Suite 2, Brooklyn, New York 11226, USA.
出版信息
J Org Chem. 2005 Nov 11;70(23):9629-31. doi: 10.1021/jo051419g.
PMID:16268648
Abstract
[Reaction: see text]. A synthesis of the title compounds, which have found use as inhibitors of certain receptor tyrosine kinases, was achieved using a Pictet-Spengler cyclization as a key step.
摘要
[反应：见正文]。通过使用Pictet-Spengler环化反应作为关键步骤，实现了用作某些受体酪氨酸激酶抑制剂的标题化合物的合成。
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