• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

微波辐射下通过铜（I）催化的多米诺三组分偶联-环化-N-芳基化反应简洁合成吲哚并1,4-二氮杂卓类化合物

Concise synthesis of indole-fused 1,4-diazepines through copper(I)-catalyzed domino three-component coupling-cyclization-N-arylation under microwave irradiation.

作者信息

Ohta Yusuke, Chiba Hiroaki, Oishi Shinya, Fujii Nobutaka, Ohno Hiroaki

机构信息

Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

出版信息

Org Lett. 2008 Aug 21;10(16):3535-8. doi: 10.1021/ol801383b. Epub 2008 Jul 11.

DOI:10.1021/ol801383b
PMID:18616342
Abstract

Indole-fused benzo-1,4-diazepines were synthesized by copper-catalyzed domino three-component coupling-indole formation- N-arylation under microwave irradiation from a simple N-mesyl-2-ethynylaniline. This method was also applicable to the formation of heterocycle-fused 1,4-diazepines.

摘要

在微波辐射下，通过铜催化的多米诺三组分偶联-吲哚形成-N-芳基化反应，从简单的N-甲磺酰基-2-乙炔基苯胺合成了吲哚并苯并-1,4-二氮杂卓。该方法也适用于杂环稠合的1,4-二氮杂卓的形成。

相似文献

1
Concise synthesis of indole-fused 1,4-diazepines through copper(I)-catalyzed domino three-component coupling-cyclization-N-arylation under microwave irradiation.微波辐射下通过铜（I）催化的多米诺三组分偶联-环化-N-芳基化反应简洁合成吲哚并1,4-二氮杂卓类化合物
Org Lett. 2008 Aug 21;10(16):3535-8. doi: 10.1021/ol801383b. Epub 2008 Jul 11.
2
Construction of nitrogen heterocycles bearing an aminomethyl group by copper-catalyzed domino three-component coupling-cyclization.铜催化的多米诺三组分偶联-环化反应构建含氨甲基的氮杂环。
J Org Chem. 2009 Sep 18;74(18):7052-8. doi: 10.1021/jo901328q.
3
Facile synthesis of 1,2,3,4-tetrahydro-beta-carbolines by one-pot domino three-component indole formation and nucleophilic cyclization.通过一锅法多米诺三组分吲哚形成和亲核环化反应简便合成1,2,3,4-四氢-β-咔啉
Org Lett. 2009 May 7;11(9):1979-82. doi: 10.1021/ol900460m.
4
Development of an efficient procedure for indole ring synthesis from 2-ethynylaniline derivatives catalyzed by CuII salts and its application to natural product synthesis.由CuII盐催化从2-乙炔基苯胺衍生物合成吲哚环的高效方法的开发及其在天然产物合成中的应用。
J Org Chem. 2004 Feb 20;69(4):1126-36. doi: 10.1021/jo035528b.
5
A facile route to polysubstituted indoles via three-component reaction of 2-ethynylaniline, sulfonyl azide, and nitroolefin.一种通过 2-乙炔苯胺、磺酰基叠氮化物和硝基烯烃的三组分反应制备多取代吲哚的简便方法。
Org Lett. 2011 Mar 4;13(5):848-51. doi: 10.1021/ol102775s. Epub 2011 Feb 7.
6
Synthesis of indoles by conjugate addition and ligand-free copper-catalyzed intramolecular arylation of activated acetylenes with o-haloanilines.通过共轭加成以及无配体铜催化的邻卤苯胺与活化乙炔的分子内芳基化反应合成吲哚。
Chemistry. 2010 Dec 27;16(48):14281-4. doi: 10.1002/chem.201002628.
7
Tunable Pd-catalyzed cyclization of indole-2-carboxylic acid allenamides: carboamination vs microwave-assisted hydroamination.可调钯催化吲哚-2-羧酸烯丙酰胺环化反应：碳氨化与微波辅助氨化的比较。
J Org Chem. 2010 Oct 15;75(20):6923-32. doi: 10.1021/jo101501u.
8
Assembly of conjugated enynes and substituted indoles via CuI/amino acid-catalyzed coupling of 1-alkynes with vinyl iodides and 2-bromotrifluoroacetanilides.通过碘化亚铜/氨基酸催化1-炔烃与乙烯基碘和2-溴三氟乙酰苯胺的偶联反应合成共轭烯炔和取代吲哚。
J Org Chem. 2007 Jun 22;72(13):4844-50. doi: 10.1021/jo070547x. Epub 2007 May 27.
9
One-pot approach to 1,2-disubstituted indoles via Cu(II)-catalyzed coupling/cyclization under aerobic conditions and its application for the synthesis of polycyclic indoles.通过铜（II）催化在有氧条件下的偶联/环化反应一锅法合成1,2-二取代吲哚及其在多环吲哚合成中的应用
J Org Chem. 2014 Oct 3;79(19):9000-8. doi: 10.1021/jo501250u. Epub 2014 Sep 22.
10
Copper-catalyzed domino annulation approaches to the synthesis of benzoxazoles under microwave-accelerated and conventional thermal conditions.在微波加速和传统热条件下，铜催化多米诺环化法合成苯并恶唑
J Org Chem. 2008 May 2;73(9):3452-9. doi: 10.1021/jo702145d. Epub 2008 Apr 1.

引用本文的文献

1
One-Pot Synthesis of Hydroxylated Alkaloids from Sugars via a Pictet-Spengler-Type Reaction.通过Pictet-Spengler型反应从糖类一锅法合成羟基化生物碱。
Molecules. 2024 Dec 3;29(23):5709. doi: 10.3390/molecules29235709.
2
A multicomponent reaction for modular assembly of indole-fused heterocycles.用于吲哚稠合杂环模块化组装的多组分反应。
Chem Sci. 2024 Mar 4;15(14):5211-5217. doi: 10.1039/d4sc00522h. eCollection 2024 Apr 3.
3
[RhCp*Cl]-Catalyzed Indole Functionalization: Synthesis of Bioinspired Indole-Fused Polycycles.[RhCp*Cl]催化的吲哚官能化反应：受生物启发的吲哚稠合多环化合物的合成
ACS Omega. 2023 Jul 25;8(31):27894-27919. doi: 10.1021/acsomega.3c02510. eCollection 2023 Aug 8.
4
Microwave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused Derivatives.微波辅助合成生物活性七元大环杂环及其稠合衍生物
Molecules. 2016 Aug 9;21(8):1032. doi: 10.3390/molecules21081032.
5
Crystal structure of 3-benzamido-1-(4-nitro-benz-yl)quinolinium tri-fluoro-methane-sulfonate.3-苯甲酰胺基-1-(4-硝基苄基)喹啉三氟甲磺酸盐的晶体结构
Acta Crystallogr E Crystallogr Commun. 2016 Apr 29;72(Pt 5):747-50. doi: 10.1107/S2056989016006423. eCollection 2016 May 1.
6
Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.现代有机合成中的可控微波加热：2004 - 2008年文献综述
Mol Divers. 2009 May;13(2):71-193. doi: 10.1007/s11030-009-9138-8. Epub 2009 Apr 21.