微波辐射下通过铜（I）催化的多米诺三组分偶联-环化-N-芳基化反应简洁合成吲哚并1,4-二氮杂卓类化合物
Concise synthesis of indole-fused 1,4-diazepines through copper(I)-catalyzed domino three-component coupling-cyclization-N-arylation under microwave irradiation.
作者信息
Ohta Yusuke, Chiba Hiroaki, Oishi Shinya, Fujii Nobutaka, Ohno Hiroaki
机构信息
Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
出版信息
Org Lett. 2008 Aug 21;10(16):3535-8. doi: 10.1021/ol801383b. Epub 2008 Jul 11.
PMID:18616342
Abstract
Indole-fused benzo-1,4-diazepines were synthesized by copper-catalyzed domino three-component coupling-indole formation- N-arylation under microwave irradiation from a simple N-mesyl-2-ethynylaniline. This method was also applicable to the formation of heterocycle-fused 1,4-diazepines.
摘要
在微波辐射下，通过铜催化的多米诺三组分偶联-吲哚形成-N-芳基化反应，从简单的N-甲磺酰基-2-乙炔基苯胺合成了吲哚并苯并-1,4-二氮杂卓。该方法也适用于杂环稠合的1,4-二氮杂卓的形成。
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