Izuel-Rami M, Cuenca Espiérrez J, García-Erce J A, Gómez-Barrera M, Carcelén Andrés J, Rabanaque Hernández M J
Servicio de Farmacia, Hospital Universitario Miguel Servet, Zaragoza.
Farm Hosp. 2005 Jul-Aug;29(4):250-7. doi: 10.1016/s1130-6343(05)73673-4.
To describe and study the effectiveness of the perioperative anaemia treatment patterns for patients older than 64 with hip fracture.
Three groups of patients were compared: Group 1: Oral iron or without iron therapy. Group 2: low doses of intravenous iron. Group 3: treated according to a blood saving programme including intravenous iron, alpha epoetin and restrictive transfusional criteria. The homogeneity of gender, age, type of fracture, ASA, preoperative period and perisurgical bleeding affecting drug consumption within the groups was analyzed. The effectiveness of the treatments was determined by means of transfusional rate, postoperative haemoglobin levels, and postoperative length of stay and infection rate.
329 patients were checked. Patients were comparable. Patients included in Group 3 were transfused less than the rest (36.5 of patients in group 3 vs. 52.0% in group 1 and 67.6% in group 3, p = 0.002). Decreases in the infection rate and mean postoperative stay in group 3 were not significant. Haemoglobin levels at 48 hours post surgery were higher in group 1 but haemoglobin levels at the seventh day post surgery were similar for the three groups.
The above mentioned blood saving programme has been observed to be effective in decreasing transfusional requirements without increasing morbidity. However, further prospective studies are needed in order to define the cost-effectiveness of this programme and to determine its role in the reduction of posttransfusional infections and postoperative length of stay.
描述并研究64岁以上髋部骨折患者围手术期贫血治疗模式的有效性。
比较三组患者:第1组:口服铁剂或不进行铁剂治疗。第2组:低剂量静脉注射铁剂。第3组:按照包括静脉注射铁剂、α促红细胞生成素和限制性输血标准的血液保护方案进行治疗。分析了各组内性别、年龄、骨折类型、美国麻醉医师协会(ASA)分级、术前阶段和影响药物使用的围手术期出血情况的同质性。通过输血率、术后血红蛋白水平、术后住院时间和感染率来确定治疗的有效性。
检查了329例患者。患者具有可比性。第3组患者的输血次数少于其他组(第3组患者为36.5%,第1组为52.0%,第2组为67.6%,p = 0.002)。第3组的感染率和术后平均住院时间的降低不显著。术后48小时第1组的血红蛋白水平较高,但术后第7天三组的血红蛋白水平相似。
上述血液保护方案已被观察到在不增加发病率的情况下有效降低输血需求。然而,需要进一步的前瞻性研究来确定该方案的成本效益,并确定其在减少输血后感染和术后住院时间方面的作用。