Makhija Praveen, Yadav Sangita, Thakur Archana
Department of Pediatrics, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi 110 002, India.
Indian Pediatr. 2005 Oct;42(10):1024-8.
Thirty-two infants above one month of age admitted to a tertiary care hospital with signs of infection and presumptive diagnosis of sepsis were included. Cytokine levels of tumor necrosis factor alpha (TNFmu) and interleukin-6 (IL 6) were estimated at admission and after 48 to 72 hr, and their relationship examined to the outcome. Significantly higher TNFalpha and IL-6 levels were seen in infants with sepsis compared to control. The TNFalpha levels significantly decreased in patients with sepsis, septic shock and the survivors, while the patients who did not survive, the levels showed no significant change after 48 hr. The initial levels of IL6 were comparatively higher in patients with septic shock and non-survivors, and increased at 48 hr of admission in patients with sepsis, septic shock and non-survivors.
纳入了32名1个月以上入住三级护理医院且有感染迹象并初步诊断为败血症的婴儿。在入院时以及48至72小时后，对肿瘤坏死因子α（TNFα）和白细胞介素-6（IL-6）的细胞因子水平进行了评估，并研究了它们与结局的关系。与对照组相比，败血症婴儿的TNFα和IL-6水平显著更高。败血症、感染性休克患者及幸存者的TNFα水平显著下降，而未存活患者在48小时后水平无显著变化。感染性休克患者和非幸存者的IL-6初始水平相对较高，败血症、感染性休克患者和非幸存者在入院48小时时IL-6水平升高。
