Harstad T W, Mason R A, Cox S M
Department of Obstetrics & Gynecology, University of Texas Southwestern Medical Center, Dallas.
Am J Perinatol. 1992 Jul;9(4):233-5. doi: 10.1055/s-2007-994778.
During normal pregnancy there is a decrease in the hematocrit due to a disproportionate increase in the blood volume compared with the red cell mass. Using a new enzyme-linked immunoassay (Amgen Diagnostics), serum erythropoietin was quantified in normal nonanemic pregnancies throughout gestation and in third trimester anemic patients. We found that the mean hematocrit in normal pregnancy reached a nadir late in the second trimester and the serum erythropoietin plateaued at a 50% increase. Those pregnancies complicated by anemia defined by a hematocrit less than 30 vol% demonstrated a statistically significant increase in serum erythropoietin above those not anemic.
在正常妊娠期间，由于血容量的增加与红细胞量不成比例，血细胞比容会降低。使用一种新的酶联免疫测定法（安进诊断公司），对整个妊娠期正常非贫血孕妇以及孕晚期贫血患者的血清促红细胞生成素进行了定量分析。我们发现，正常妊娠时的平均血细胞比容在妊娠中期晚期降至最低点，血清促红细胞生成素增加50%后趋于平稳。那些血细胞比容低于30%（体积分数）定义的贫血妊娠患者，其血清促红细胞生成素较非贫血患者有统计学上的显著增加。
