Herson V C, Block C, Eisenfeld L I, Maderazo E, Krause P J
Department of Pediatrics, Hartford Hospital, Connecticut 06115.
Am J Perinatol. 1992 Jul;9(4):285-8. doi: 10.1055/s-2007-994791.
The ability of the neonate to mount an adequate polymorphonuclear leukocyte (PMN) response, either quantitatively or functionally, is impaired. To assess whether neonatal PMN number and function are altered by labor and delivery, three groups of infants were studied: cesarean section without labor (10), cesarean section after labor (10), and vaginal delivery (11). PMN counts were higher in the groups undergoing labor (p less than 0.01) compared with the cesarean section without labor group. Similarly, the labor groups had evidence of complement activation (increased C3a desarg) compared with the cesarean section without labor group. No differences were noted between the groups in measures of PMN motility (chemokinesis or chemotaxis) or PMN degranulation (plasma lysozyme), suggesting that normal labor and delivery does not contribute to the general PMN dysfunction of the neonate.
新生儿在数量或功能上产生足够多形核白细胞（PMN）反应的能力受损。为评估分娩过程是否会改变新生儿PMN的数量和功能，研究了三组婴儿：未经历分娩的剖宫产（10例）、经历分娩后的剖宫产（10例）和阴道分娩（11例）。与未经历分娩的剖宫产组相比，经历分娩的组中PMN计数更高（p<0.01）。同样，与未经历分娩的剖宫产组相比，经历分娩的组有补体激活的证据（C3a去精氨酸增加）。在PMN运动性（化学运动或趋化性）或PMN脱颗粒（血浆溶菌酶）指标上，各组之间未观察到差异，这表明正常的分娩过程不会导致新生儿普遍的PMN功能障碍。
