Krishna D R, Shekar M S
Drug Metabolism, Cancer and Aging Research Lab, Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India.
Methods Find Exp Clin Pharmacol. 2005 Oct;27(8):559-67. doi: 10.1358/mf.2005.27.8.928310.
Ethnicity is a demographic variable that plays an important role in interindividual variability of drug metabolism and response. The genetic variations of drug-metabolizing enzymes exhibiting interindividual differences of drug metabolism also show differences between populations. The reason for this is that the frequency of a polymorphism is found to differ between populations. The other reason is that different variants are seen in different populations. Most drugs are biotransformed in the body by cytochrome P450. The CYP3A isozymes are responsible for the metabolism of 50-60% of all currently prescribed drugs. Studies have shown that there is variability in CYP3A activity and also inter-ethnic differences in CYP3A-mediated drug metabolism. The purpose of this review is to focus on the genetic polymorphism and ethnic variations in CYP3A-mediated oxidative drug metabolism.
种族是一个人口统计学变量，在药物代谢和反应的个体间变异性中起重要作用。表现出药物代谢个体差异的药物代谢酶的基因变异在不同人群之间也存在差异。原因在于，一种多态性的频率在不同人群中有所不同。另一个原因是在不同人群中可见不同的变异体。大多数药物在体内通过细胞色素P450进行生物转化。CYP3A同工酶负责目前所有处方药中50%-60%的代谢。研究表明，CYP3A活性存在变异性，并且在CYP3A介导的药物代谢中也存在种族间差异。本综述的目的是聚焦于CYP3A介导的氧化药物代谢中的基因多态性和种族差异。
