Engel A F, Oomen J L T, Knol D L, Cuesta M A
Department of Surgery, Zaans Medical Centre, PO Box 210, 1500 EE Zaandam, The Netherlands.
Br J Surg. 2005 Dec;92(12):1526-32. doi: 10.1002/bjs.5153.
The aim of this study was to quantify factors related to operative mortality after colorectal resection in the Netherlands.
Multilevel logistic regression modelling was used. Institutional effects were calculated with and without adjustment for specific patient (age, sex, urgency of operation) and hospital (number of procedures, type of hospital) characteristics. All adult Dutch patients who underwent primary colorectal resection between 1994 and 1999 were included, except those who had (sub)total colectomy or local rectal resection.
A total of 67 594 patients underwent colorectal resection. The in-hospital mortality rate was 7.0 per cent (elective 3.9 per cent, acute 14.3 per cent). Acute operation (odds ratio 3.89) and age (odds ratios 2.63, 5.23 and 10.13 for patients aged 50-69, 70-79 and 80 or more years respectively compared with those aged less than 50 years) had the strongest effects, followed by male sex (odds ratio 1.48) and type of hospital. There was no difference in operative mortality rate between low-, medium- and high-volume hospitals.
In the Netherlands, advanced age and acute operation are by far the most important factors related to operative mortality after colorectal resection. Male sex and type of hospital have only a modest effect, and there is no discernible effect of hospital volume.
本研究旨在量化荷兰结直肠切除术后与手术死亡率相关的因素。
采用多水平逻辑回归模型。在调整和未调整特定患者(年龄、性别、手术紧迫性)及医院(手术例数、医院类型)特征的情况下计算机构效应。纳入1994年至1999年间接受初次结直肠切除的所有成年荷兰患者,但不包括接受(次)全结肠切除术或局部直肠切除术的患者。
共有67594例患者接受了结直肠切除术。住院死亡率为7.0%(择期手术为3.9%,急诊手术为14.3%)。急诊手术(比值比3.89)和年龄(50 - 69岁、70 - 79岁及80岁及以上患者与年龄小于50岁患者相比,比值比分别为2.63、5.23和10.13)的影响最为显著,其次是男性(比值比1.48)和医院类型。低、中、高手术量医院之间的手术死亡率无差异。
在荷兰,高龄和急诊手术是结直肠切除术后与手术死亡率相关的最重要因素。男性和医院类型的影响较小,且医院手术量无明显影响。