Mouridsen H T, Andersen J, Andersen K W, Axelsson C, Blichert-Toft M, Dombernowsky P, Hansen M, Krag C, Overgård M, Rasmussen B B
Department of Oncology, Rigshospitalet, Copenhagen, Denmark.
J Natl Cancer Inst Monogr. 1992(11):163-6.
Classical prognostic factors were analyzed in patients with low-risk primary breast cancer, defined as absence of tumor-positive axillary lymph nodes, tumor size less than or equal to 5 cm in diameter, and no invasion into skin or deep fascia. The primary surgical treatment was total mastectomy and lower axillary dissection. None of the patients received adjuvant therapy. Between 1977 and 1990, 7315 patients entered the study, and at the time of this analysis (January 1, 1990), the median follow-up time is 5 years. In univariate analyses, the following variables were significantly related to recurrence-free survival: age in premenopausal patients; tumor size; number of negative nodes removed; histological grade; and in premenopausal patients, estrogen receptor and progesterone (PgR) status. In multivariate analyses, age in premenopausal patients was the most important factor, followed by tumor size and histological grade, whereas PgR status in premenopausal patients was just of borderline significance. These variables should be included in multivariate analyses testing the value of more recently introduced prognostic factors.
对低风险原发性乳腺癌患者的经典预后因素进行了分析，低风险原发性乳腺癌定义为无肿瘤阳性腋窝淋巴结、肿瘤直径小于或等于5厘米且未侵犯皮肤或深筋膜。主要手术治疗方式为全乳切除术和低位腋窝清扫术。所有患者均未接受辅助治疗。1977年至1990年期间，7315例患者进入该研究，在本次分析时（1990年1月1日），中位随访时间为5年。在单因素分析中，以下变量与无复发生存显著相关：绝经前患者的年龄；肿瘤大小；切除的阴性淋巴结数量；组织学分级；以及绝经前患者的雌激素受体和孕激素（PgR）状态。在多因素分析中，绝经前患者的年龄是最重要的因素，其次是肿瘤大小和组织学分级，而绝经前患者的PgR状态仅具有临界显著性。在检验最近引入的预后因素价值的多因素分析中应纳入这些变量。
