Blichert-Toft M, Rose C, Andersen J A, Overgaard M, Axelsson C K, Andersen K W, Mouridsen H T
Department of Surgery, Odense University Hospital, Denmark.
J Natl Cancer Inst Monogr. 1992(11):19-25.
The Danish Breast Cancer Cooperative Group (DBCG) conducted a randomized trial comparing breast conservation with mastectomy in patients with invasive mammary carcinoma. From January 1983 to March 1989, the trial accrued a total of 1153 women. Of this number, 905 patients (79%) were randomly assigned to one of the two treatment options, whereas 248 patients (21%) did not accept randomization. Of the randomly assigned patients, 90% received the surgical option to which they had been originally assigned. In the breast conservation arm the tumor was excised with the intention of obtaining free margins determined at gross examination, and radiotherapy was subsequently administered to residual breast tissue. The axilla was dissected in all instances. Patient and tumor characteristics were similar in the two randomization arms. The median follow-up time was 40 months. At 6 years of life-table analysis the probability of recurrence-free survival was 70% in the breast conservation arm against 66% in the mastectomy arm. Survival figures were 79% against 82%, respectively.
丹麦乳腺癌协作组（DBCG）开展了一项随机试验，比较浸润性乳腺癌患者保乳手术与乳房切除术的疗效。1983年1月至1989年3月，该试验共纳入1153名女性。其中，905例患者（79%）被随机分配至两种治疗方案之一，而248例患者（21%）未接受随机分组。在随机分组的患者中，90%接受了最初分配的手术方案。在保乳组，切除肿瘤的目的是在大体检查时获得切缘阴性，随后对残留乳腺组织进行放疗。所有病例均进行腋窝清扫。两个随机分组组的患者和肿瘤特征相似。中位随访时间为40个月。在6年生命表分析中，保乳组无复发生存概率为70%，乳房切除组为66%。生存率分别为79%和82%。
