Lagopoulos Jim, Malhi Gin S, Ivanovski Belinda, Cahill Catherine M, Morris John G L
School of Psychiatry, The University of New South Wales, Australia.
Expert Rev Neurother. 2005 Nov;5(6):803-10. doi: 10.1586/14737175.5.6.803.
Depression is one of the most frequent comorbidities occurring in Parkinson's disease, affecting up to 50% of patients. Depression is associated with severe negative symptoms and has been shown to contribute to an increased rate of decline of both cognitive and motor function, profoundly impacting on the patient's quality of life. The symptoms of depression overlap with the motor features of Parkinson's disease, making detection difficult. Moreover, the lack of specialized screening tools means that depression remains undiagnosed and untreated in a high percentage of patients. However, depression in Parkinson's disease, when identified early, can be effectively treated with a variety of antidepressant medications, improving quality of life and preserving daily function. The focus of this review is to provide an overview of current knowledge regarding depression in Parkinson's disease, followed by a practical discussion addressing the issues of the detection, diagnosis and treatment.
抑郁症是帕金森病中最常见的共病之一，影响多达50%的患者。抑郁症与严重的阴性症状相关，并且已被证明会导致认知和运动功能下降速度加快，对患者的生活质量产生深远影响。抑郁症的症状与帕金森病的运动特征重叠，使得检测变得困难。此外，缺乏专门的筛查工具意味着在很大比例的患者中，抑郁症仍未被诊断和治疗。然而，帕金森病中的抑郁症如果能早期识别，可以用多种抗抑郁药物有效治疗，从而提高生活质量并维持日常功能。本综述的重点是概述目前关于帕金森病中抑郁症的知识，随后进行实际讨论，探讨检测、诊断和治疗问题。
