A组链球菌感染：1985 - 2002年意大利中部某地区的流行趋势及菌株emm分型
Group A streptococcal infections: trend and strain emm typing in an area of central Italy, 1985-2002.
作者信息
Mencarelli M, Corbisiero R, Padula M G, Galgani I, Stolzuoli L, Cellesi C
机构信息
Clinic and Laboratory of Infectious Diseases, Department of Molecular Biology, University of Siena, Siena, Italy.
出版信息
Epidemiol Infect. 2005 Dec;133(6):1107-11. doi: 10.1017/S0950268805004140.
A retrospective study of group A streptococcal (GAS) infections was performed for the period 1985-2002 in an area of central Italy. Although very severe diseases such as streptococcal toxic shock syndrome (STSS) were observed, a general increase in invasive infections was not found. Isolates of GAS were classified by M protein genotyping (emm typing) and analysed according to their origin from invasive and non-invasive infections. The predominant emm types were types 1, 4 and 12, followed by types 3, 6 and 28. During the study period the proportion of isolates of types 1 and 12 fell, while other types (3, 6, 22, 28 and 77) appeared. Isolates from invasive and non-invasive infections shared several emm types; however, most invasive strains belonged to five types only (types 1, 4, 12, 28 and 77), while non-invasive isolates were generally more heterogeneous.
1985年至2002年期间，在意大利中部某地区开展了一项关于A组链球菌（GAS）感染的回顾性研究。尽管观察到了诸如链球菌中毒性休克综合征（STSS）等非常严重的疾病，但未发现侵袭性感染总体增加。通过M蛋白基因分型（emm分型）对GAS分离株进行分类，并根据其来自侵袭性和非侵袭性感染的来源进行分析。主要的emm型为1型、4型和12型，其次是3型、6型和28型。在研究期间，1型和12型分离株的比例下降，而其他类型（3型、6型、22型、28型和77型）出现。来自侵袭性和非侵袭性感染的分离株共有几种emm型；然而，大多数侵袭性菌株仅属于五种类型（1型、4型、12型、28型和77型），而非侵袭性分离株通常更为多样。
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