来自意大利罗马儿科咽喉分离株的A组链球菌基因型
Group A streptococcal genotypes from pediatric throat isolates in Rome, Italy.
作者信息
Dicuonzo G, Gherardi G, Lorino G, Angeletti S, De Cesaris M, Fiscarelli E, Bessen D E, Beall B
机构信息
Department of Medicine and Microbiology, Università Campus Bio-Medico, Rome, Italy.
出版信息
J Clin Microbiol. 2001 May;39(5):1687-90. doi: 10.1128/JCM.39.5.1687-1690.2001.
Abstract
In a study assessing genetic diversity, 114 group A streptococcus (GAS) isolates were recovered from pediatric pharyngitis patients in Rome, Italy. These isolates comprised 22 different M protein gene (emm) sequence types, 14 of which were associated with a distinct serum opacity factor/fibronectin binding protein gene (sof) sequence type. Isolates with the same emm gene sequence type generally shared a highly conserved chromosomal macrorestriction profile. In three instances, isolates with dissimilar macrorestriction profiles had identical emm types; in each of these cases multilocus sequence typing revealed that isolates with the same emm type were clones having the same allelic profiles. Ninety-eight percent of the pharyngeal isolates had emm types previously found to be highly associated with mga locus gene patterns commonly found in pharyngeal GAS isolates.
摘要
在一项评估基因多样性的研究中，从意大利罗马的小儿咽炎患者中分离出114株A组链球菌（GAS）。这些分离株包含22种不同的M蛋白基因（emm）序列类型，其中14种与独特的血清混浊因子/纤连蛋白结合蛋白基因（sof）序列类型相关。具有相同emm基因序列类型的分离株通常共享高度保守的染色体宏观限制性图谱。在三个实例中，具有不同宏观限制性图谱的分离株具有相同的emm类型；在每种情况下，多位点序列分型显示具有相同emm类型的分离株是具有相同等位基因图谱的克隆。98%的咽部分离株具有先前发现与咽部GAS分离株中常见的mga基因座基因模式高度相关的emm类型。
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本文引用的文献
1
Association of a serum opacity reaction with serological type in Streptococcus pyogenes.化脓性链球菌中血清混浊反应与血清型的关联。
J Gen Microbiol. 1961 Jul;25:347-52. doi: 10.1099/00221287-25-3-347.
2
Multilocus sequence typing of Streptococcus pyogenes and the relationships between emm type and clone.化脓性链球菌的多位点序列分型以及致热外毒素基因（emm）型与克隆之间的关系。
Infect Immun. 2001 Apr;69(4):2416-27. doi: 10.1128/IAI.69.4.2416-2427.2001.
3
Contrasting molecular epidemiology of group A streptococci causing tropical and nontropical infections of the skin and throat.引起皮肤和咽喉热带及非热带感染的A组链球菌的分子流行病学对比
J Infect Dis. 2000 Oct;182(4):1109-16. doi: 10.1086/315842. Epub 2000 Sep 8.
4
emm and sof gene sequence variation in relation to serological typing of opacity-factor-positive group A streptococci.与不透明因子阳性A群链球菌血清学分型相关的emm和sof基因序列变异
Microbiology (Reading). 2000 May;146 ( Pt 5):1195-1209. doi: 10.1099/00221287-146-5-1195.
5
emm typing and validation of provisional M types for group A streptococci.A群链球菌临时M型的分型及验证
Emerg Infect Dis. 1999 Mar-Apr;5(2):247-53. doi: 10.3201/eid0502.990209.
6
Genetic linkage of exotoxin alleles and emm gene markers for tissue tropism in group A streptococci.A群链球菌中毒素等位基因与组织嗜性的emm基因标记的遗传连锁
J Infect Dis. 1999 Mar;179(3):627-36. doi: 10.1086/314631.
7
Streptococcal emm types associated with T-agglutination types and the use of conserved emm gene restriction fragment patterns for subtyping group A streptococci.与T凝集类型相关的链球菌emm型以及使用保守的emm基因限制性片段模式对A组链球菌进行亚型分析
J Med Microbiol. 1998 Oct;47(10):893-8. doi: 10.1099/00222615-47-10-893.
8
Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms.多位点序列分型：一种用于鉴定致病微生物群体内克隆的便捷方法。
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3140-5. doi: 10.1073/pnas.95.6.3140.
9
A genetic-based evaluation of the principal tissue reservoir for group A streptococci isolated from normally sterile sites.对从通常无菌部位分离出的A组链球菌主要组织储存库进行基于基因的评估。
J Infect Dis. 1997 Jul;176(1):177-82. doi: 10.1086/514020.
10
Recombinant, octavalent group A streptococcal M protein vaccine.重组八价A组链球菌M蛋白疫苗
Vaccine. 1996 Jul;14(10):944-8. doi: 10.1016/0264-410x(96)00050-3.
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