脑脊液中β淀粉样蛋白42和tau蛋白水平与艾滋病痴呆综合征相关。

CSF amyloid beta42 and tau levels correlate with AIDS dementia complex.

作者信息

Brew B J, Pemberton L, Blennow K, Wallin A, Hagberg L

机构信息

Department of Neurology, St. Vincent's Hospital, University of New South Wales, Sydney, Australia.

出版信息

Neurology. 2005 Nov 8;65(9):1490-2. doi: 10.1212/01.wnl.0000183293.95787.b7.

DOI:10.1212/01.wnl.0000183293.95787.b7

PMID:16275845

Abstract

There is concern that AIDS dementia complex (ADC) may be complicated by Alzheimer disease (AD). Because AD presence and risk are related to CSF beta-amyloid(1-42) (Abeta42), total tau (t-tau), and phosphorylated tau (p-tau), the authors examined these in ADC, AD, and controls. ADC had significantly decreased CSF Abeta42 and increased t-tau and p-tau concentrations similar to AD, suggesting that ADC may be associated with AD or an AD-like process.

摘要

有人担心艾滋病痴呆综合征（ADC）可能并发阿尔茨海默病（AD）。由于AD的存在和风险与脑脊液β-淀粉样蛋白（1-42）（Aβ42）、总tau蛋白（t-tau）和磷酸化tau蛋白（p-tau）有关，作者对ADC、AD患者及对照组进行了这些指标的检测。ADC患者脑脊液Aβ42显著降低，t-tau和p-tau浓度升高，与AD患者相似，提示ADC可能与AD或类AD过程有关。