Arienta C, Caroli M, Balbi S
Institute of Neurosurgery, University of Milano, Italy.
Aging (Milano). 1992 Mar;4(1):29-33. doi: 10.1007/BF03324059.
Forty-six cases of intracranial meningioma in patients above 70 years of age form the basis of this study; 34 underwent surgery while 12 did not. The decision to operate was based on the general condition of the patient, evaluated according to the Karnofsky index, neurological conditions, the site and dimensions of the tumor, and the presence of peritumoral edema. The post-surgical mortality rate was 11.5% at 30 days, and 20% at 3 months. Long-term follow-up in both patient groups ranged from 1 to 5 years, and quality of life was evaluated by the Karnofsky index. Five operated patients died during follow-up (only 1 from intracranial pathology); the 22 survivors showed further improvement in their grading level compared to scores immediately following surgery. Among the unoperated patients, 6 died within two years of diagnosis, all from causes related to intracranial pathology; among the survivors, the Karnofsky index was unchanged in 2, and diminished in the other 4 cases.
本研究以46例70岁以上的颅内脑膜瘤患者为基础;34例接受了手术,12例未接受手术。手术决策基于患者的一般状况(根据卡诺夫斯基指数评估)、神经状况、肿瘤的位置和大小以及瘤周水肿情况。术后30天的死亡率为11.5%,3个月时为20%。两组患者的长期随访时间为1至5年,生活质量通过卡诺夫斯基指数进行评估。5例接受手术的患者在随访期间死亡(仅1例死于颅内病变);22例幸存者与术后即刻评分相比,分级水平进一步提高。在未接受手术的患者中,6例在诊断后两年内死亡,均死于与颅内病变相关的原因;在幸存者中,2例的卡诺夫斯基指数未变,另外4例有所下降。