Regland B, Gottfries C G, Lindstedt G
Department of Psychiatry and Neurochemistry, St. Jörgen Hospital, Göteborg, Sweden.
Aging (Milano). 1992 Mar;4(1):35-41. doi: 10.1007/BF03324062.
Serum concentrations of group I pepsinogens (pepsinogen-I) and gastrin were determined in patients with dementia disorders in order to assess the relationship, if any, between these indices of gastric mucosal function and serum cobalamin (vitamin B12) levels. A significant positive correlation between pepsinogen-I and B12 and, as expected, an inverse relationship between gastrin and pepsinogen-I concentrations was found, indicating that vitamin B12 deficiency was mainly determined by gastric mucosal atrophy (atrophic gastritis) in this West-Swedish sample of patients with dementia disorders. Patients with low B12 but normal gastrin and pepsinogen-I concentrations should, therefore, be further evaluated for possible nutritional deficiency, as well as nongastric causes of poor B12 assimilation from the diet.
测定了痴呆症患者的血清I组胃蛋白酶原（胃蛋白酶原-I）和胃泌素浓度，以评估这些胃黏膜功能指标与血清钴胺素（维生素B12）水平之间是否存在关系。发现胃蛋白酶原-I与维生素B12之间存在显著正相关，并且正如预期的那样，胃泌素与胃蛋白酶原-I浓度之间存在负相关，这表明在瑞典西部这个痴呆症患者样本中，维生素B12缺乏主要由胃黏膜萎缩（萎缩性胃炎）决定。因此，对于维生素B12水平低但胃泌素和胃蛋白酶原-I浓度正常的患者，应进一步评估是否存在可能的营养缺乏以及饮食中维生素B12吸收不良的非胃源性原因。
