（SLN×C3H/He）F1肥胖小鼠的一些生理特征。
Some physiological characteristics of (SLN X C3H/He)F1 obese mice.
作者信息
Nagasawa H, Naito T, Fujii Y, Yamamoto K, Ishimoto S
机构信息
Experimental Animal Research Laboratory, Meiji University, Kanagawa, Japan.
出版信息
In Vivo. 1992 Jan-Feb;6(1):65-7.
(SLN x C3H/He)F1 mice of both sexes showed significantly heavier body weights than the parental strains associated with the higher food intake and an accumulation of adipose tissue in the subcutaneous and the abdominal regions. Furthermore, serum levels of free fatty acid and growth hormone of F1 mice were higher and lower, respectively, than those of the parental strains. The results indicate that the obesity of these F1 mice is ascribed to excess food intake and metabolic disorders and they are promising as an animal model for the study of several diseases related to obesity.
（SLN×C3H/He）F1代雌雄小鼠体重均显著高于亲本品系，伴有更高的食物摄入量以及皮下和腹部脂肪组织堆积。此外，F1代小鼠的游离脂肪酸血清水平高于亲本品系，而生长激素血清水平则低于亲本品系。结果表明，这些F1代小鼠的肥胖归因于食物摄入过量和代谢紊乱，它们有望成为研究几种与肥胖相关疾病的动物模型。
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