Bassukas I D, Maurer-Schultze B
Inst. F. Mediz. Strahlenkunde, Univ. Würzburg, Germany.
In Vivo. 1992 Jan-Feb;6(1):93-6.
Growth curves of 26 EO 771 adenocarcinomas transplanted under identical conditions into 26 syngeneic C57bl/6 male mice of the same age but with different body weight were analyzed using the method of the recursion formula of the Gompertz function. The results of this analysis were then related to the body weight of the animals at the time of tumor implantation. Although all tumors grew according to the Gompertz mode of growth, the growth curves differed from each other. Moreover, there is a statistically significant correlation between the parameters of the individual growth curves and the corresponding animal weight at the time of tumor implantation (p less than 0.025). In animals with higher body weight the tumors grew with a higher initial growth rate and subsequently with a faster growth deceleration compared to animals with lower body weight. The physiological basis for this relationship is unknown but the question arises whether this relationship also has some meaning for human malignancies.
采用Gompertz函数递归公式法，分析了在相同条件下移植到26只年龄相同但体重不同的同基因C57bl/6雄性小鼠体内的26个EO 771腺癌的生长曲线。然后将该分析结果与肿瘤植入时动物的体重相关联。尽管所有肿瘤均按照Gompertz生长模式生长，但生长曲线彼此不同。此外，个体生长曲线参数与肿瘤植入时相应动物体重之间存在统计学显著相关性（p小于0.025）。与体重较低的动物相比，体重较高的动物体内肿瘤的初始生长速率更高，随后生长减速更快。这种关系的生理基础尚不清楚，但问题是这种关系对人类恶性肿瘤是否也有意义。
