Calzavara-Pinton Piergiacomo, Leone Giovanni, Venturini Marina, Sala Raffaella, Colombo Delia, La Parola Ilaria Lesnoni, Sitzia Nathalie, Ferraro Carmela, Picardo Mauro
Department of Dermatology, Azienda Spedali Civili di Brescia, Brescia, Italy.
Eur J Dermatol. 2005 Nov-Dec;15(6):470-3.
Sequential therapy may improve the efficacy and safety of single treatments for severe psoriasis. We compared sequential Cyclosporin A and narrow-band UVB phototherapy versus narrow-band UVB phototherapy alone. A group of 30 patients with severe psoriasis received 3 mg/kg/day Cyclosporin A for 4 weeks. Afterwards, Cyclosporin A was rapidly tapered and phototherapy begun. An additional 30 patients received phototherapy alone. Treatments were given until psoriasis cleared or until partial improvement was achieved without further amelioration despite another week of treatment. Both treatments were highly effective and well tolerated but sequential therapy was more effective in lesions of UV-shielded body areas; itching disappeared more quickly. The cumulative narrow-band UVB dosages and number of exposures were lower. No difference was seen at follow-up extended up to 9 months. Sequential therapy was well tolerated and allowed for the reduction of narrow-band UVB dosage and exposures, quick relief of itching and improvement of UV-shielded lesions.
序贯疗法可能会提高重度银屑病单一治疗方法的疗效和安全性。我们比较了环孢素A与窄谱中波紫外线光疗序贯疗法和单纯窄谱中波紫外线光疗。一组30例重度银屑病患者接受了4周每天3mg/kg的环孢素A治疗。之后，迅速减少环孢素A用量并开始光疗。另外30例患者仅接受光疗。治疗持续进行直至银屑病消退，或在又治疗一周后虽未进一步改善但已部分改善。两种治疗均非常有效且耐受性良好，但序贯疗法对紫外线防护身体部位的皮损更有效；瘙痒消失得更快。累积窄谱中波紫外线剂量和照射次数更低。随访延长至9个月时未发现差异。序贯疗法耐受性良好，可减少窄谱中波紫外线剂量和照射次数，迅速缓解瘙痒并改善紫外线防护部位的皮损。
