Inadomi Toru
Department of Dermatology, 180 Nishi-Araijuku, Kawaguchi, Saitama 333-0833 Japan.
Eur J Dermatol. 2005 Nov-Dec;15(6):492-4.
An 82-year-old man with Sister Mary Joseph's nodule (SMJN) is reported. He had a past history of gastric cancer, which had been removed in its early stage. Histopathological findings, in which CA19-9 and other markers, such as PCNA and p53, were strongly positive in SMJN but negative in specimens from the gastric cancer, suggested that the nodule had derived from another internal malignancy and a detailed search led to the discovery of a pancreatic cancer.
本文报道了一名82岁患有玛丽·约瑟夫修女结节（SMJN）的男性患者。他既往有胃癌病史，早期已行手术切除。组织病理学检查发现，CA19-9以及其他标志物，如增殖细胞核抗原（PCNA）和p53，在SMJN中呈强阳性，但在胃癌标本中呈阴性，提示该结节源自另一种体内恶性肿瘤，进一步详细检查发现了胰腺癌。
