Holt Richard I G
Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK.
J Psychopharmacol. 2005 Nov;19(6 Suppl):6-15. doi: 10.1177/0269881105058377.
Obesity is a chronic relapsing condition associated with significant morbidity and premature mortality. The prevalence of obesity has increased dramatically over the last 20 years and continues to do so, primarily as a result of changes in dietary intake and exercise patterns. There are considerable challenges associated with the management of the obesity epidemic involving both public health policies and individual treatment. Management of the obese individual involves lifelong lifestyle change for all, drugs for some, and surgery for a few. Appropriate selection of patients and the setting of realistic goals are crucial to the success of any weight-reducing programme. The aim of obesity management is to reduce associated morbidity and mortality, not necessarily to restore normal body weight. While the current trends in obesity are depressing, a better understanding of the pathophysiology and treatment of the condition should allow the clinician to be more optimistic for the future.
肥胖是一种慢性复发性疾病，与显著的发病率和过早死亡相关。在过去20年中，肥胖的患病率急剧上升，并且仍在继续，这主要是由于饮食摄入和运动模式的改变。肥胖流行的管理面临诸多挑战，涉及公共卫生政策和个体治疗。肥胖个体的管理对所有人来说都需要终身改变生活方式，对一些人来说需要药物治疗，对少数人来说需要手术治疗。正确选择患者并设定现实的目标对于任何减肥计划的成功至关重要。肥胖管理的目的是降低相关的发病率和死亡率，不一定是恢复正常体重。虽然目前肥胖的趋势令人沮丧，但对该疾病病理生理学和治疗方法的更好理解应使临床医生对未来更乐观。
