Omron Edward M
Division of Pulmonary Medicine, National Naval Medical Center, Bethesda, MD, USA.
J Intensive Care Med. 2005 Nov-Dec;20(6):317-26. doi: 10.1177/0885066605279955.
The main objective of this study was to assess the relationship of standard base excess (SBE) to delta strong ion difference effective (DeltaSIDe) in critical illness. Critical illness is characterized by variable plasma nonvolatile weak acid components (DeltaA(-)), and SBE becomes discordant with DeltaSIDe. The author hypothesized that both acid-base models are equivalent when SBE and DeltaSIDe are corrected for DeltaA(-). A retrospective chart review was performed to assess this hypothesis by looking at changes in SBE, DeltaSIDe, and DeltaA(-) in 30 coronary artery bypass graft surgery patients, 30 severe sepsis patients, and 15 diabetic ketoacidosis patients. SBE equals the sum of the DeltaSIDe and DeltaA(-). The SBE quantifies the magnitude of the metabolic acid-base derangement, the DeltaSIDe quantifies the plasma strong cation/anion imbalance, and the DeltaA(-) quantifies the magnitude of the hypoalbuminemic alkalosis. The partitioning of SBE into physicochemical components can facilitate analyses of complex acid-base disorders in critical illness.
本研究的主要目的是评估危重症中标准碱剩余（SBE）与有效强离子差（DeltaSIDe）之间的关系。危重症的特征是血浆非挥发性弱酸成分（DeltaA(-)）可变，且SBE与DeltaSIDe不一致。作者假设，当针对DeltaA(-)对SBE和DeltaSIDe进行校正时，两种酸碱模型是等效的。通过回顾30例冠状动脉搭桥手术患者、30例严重脓毒症患者和15例糖尿病酮症酸中毒患者的SBE、DeltaSIDe和DeltaA(-)的变化，进行了一项回顾性图表审查，以评估这一假设。SBE等于DeltaSIDe与DeltaA(-)之和。SBE量化代谢性酸碱紊乱的程度，DeltaSIDe量化血浆强阳离子/阴离子失衡，DeltaA(-)量化低白蛋白血症性碱中毒的程度。将SBE划分为物理化学成分有助于分析危重症中的复杂酸碱紊乱。
