Gonzalez Javier, Gilbert Mark R
MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA.
Curr Opin Neurol. 2005 Dec;18(6):632-8. doi: 10.1097/01.wco.0000191510.14627.d2.
Astrocytomas are the most common primary brain tumors. We will review recent developments in the understanding of the biology of these neoplasms and recent trials demonstrating promising improvements in the survival of patients with malignant gliomas.
Temozolomide along with radiation has become the standard of care for patients with newly diagnosed glioblastoma. Nonetheless, despite this advance in treatment, these tumors remain incurable. Biological markers and alternative treatment regimens will likely improve survival in patients with high-grade gliomas.
A recent study demonstrating the benefit of combined temozolomide and radiation provides a platform on which to build new treatment regimens. Further developments in the understanding of the biology of these tumors will permit specific interventions in selected patients that ultimately will improve outcomes.
星形细胞瘤是最常见的原发性脑肿瘤。我们将回顾对这些肿瘤生物学理解的最新进展，以及近期显示恶性胶质瘤患者生存率有望提高的试验。
替莫唑胺联合放疗已成为新诊断胶质母细胞瘤患者的标准治疗方案。尽管如此，尽管治疗有了这一进展，但这些肿瘤仍然无法治愈。生物标志物和替代治疗方案可能会提高高级别胶质瘤患者的生存率。
最近一项证明替莫唑胺与放疗联合使用有益的研究提供了一个构建新治疗方案的平台。对这些肿瘤生物学理解的进一步发展将允许对选定患者进行特定干预，最终改善治疗结果。
