Chiao Elizabeth Y, Krown Susan E, Stier Elizabeth A, Schrag Deborah
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
J Acquir Immune Defic Syndr. 2005 Dec 1;40(4):451-5. doi: 10.1097/01.qai.0000159669.80207.12.
Squamous cell carcinoma of the anal canal (SCCA) is etiologically linked to human papillomavirus, and its incidence is increased among the immunosuppressed. We used data from the Surveillance, Epidemiology, and End Results program to analyze the incidence of SCCA in relation to 3 separate periods during the HIV epidemic: the pre-HIV era (1973-1981), the HIV era (1982-1995), and the highly active antiretroviral treatment (HAART) era (1996-2001). The incidence per 100,000 population of SCCA increased from 0.6 in the pre-HIV era to 0.8 in the HIV era and to 1.0 in the HAART era. The gap in SCCA incidence between women and men decreased from a ratio of 1.6:1 in the pre-HIV era to 1.5:1 in the HIV era and to 1.2:1 in the HAART era. There was a significant increase in incidence rates among men and women aged 30 to 54 years in the HAART era compared with the HIV era. Men were more likely to be diagnosed with early-stage disease, but they were less likely than women to receive radiation therapy. The incidence of SCCA has particularly increased among men and those between 30 and 54 years of age since the introduction of HAART.
肛管鳞状细胞癌（SCCA）在病因上与人乳头瘤病毒有关，在免疫抑制人群中的发病率会升高。我们利用监测、流行病学和最终结果计划的数据，分析了在艾滋病流行期间3个不同阶段SCCA的发病率：艾滋病前时代（1973 - 1981年）、艾滋病时代（1982 - 1995年）和高效抗逆转录病毒治疗（HAART）时代（1996 - 2001年）。SCCA每10万人的发病率从艾滋病前时代的0.6升至艾滋病时代的0.8，再升至HAART时代的1.0。SCCA发病率的性别差异从艾滋病前时代的1.6:1降至艾滋病时代的1.5:1，再降至HAART时代的1.2:1。与艾滋病时代相比，HAART时代30至54岁男性和女性的发病率显著增加。男性更有可能被诊断为早期疾病，但与女性相比，他们接受放射治疗的可能性较小。自引入HAART以来，SCCA的发病率在男性以及30至54岁人群中尤其增加。
