Elise Arrivé, France Anaky Marie, Louise Wemin Marie, Bata Diabate, François Rouet, Roger Salamon, Philippe Msellati
Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Bordeaux, France.
J Acquir Immune Defic Syndr. 2005 Dec 1;40(4):498-500. doi: 10.1097/01.qai.0000168180.76405.5f.
African HIV-infected children benefit from access to antiretroviral treatments but little is known about their adherence. A cross-sectional assessment of adherence to highly active antiretroviral therapy was conducted among a group of children recruited in an observational cohort in Abidjan, Côte d'Ivoire. Adherence was determined by a 1-month recall by child or caregiver, with full adherence signifying no interruptions in the prior month. One-third reported less than full adherence. Undetectable viral load was associated with full adherence in a subset of children with a P value <10% (P = 0.098). As compared with children with full adherence, those with less than full adherence were significantly older and more likely to be taking efavirenz. These findings underscore the necessity of assessing and supporting children's adherence routinely in AIDS care institutions.
非洲感染艾滋病毒的儿童受益于抗逆转录病毒治疗，但对他们的治疗依从性却知之甚少。在科特迪瓦阿比让的一个观察性队列中招募了一组儿童，对他们接受高效抗逆转录病毒疗法的依从性进行了横断面评估。依从性由儿童或照顾者进行1个月的回顾来确定，完全依从表示前一个月没有中断治疗。三分之一的人报告称依从性不完全。在一部分儿童中，病毒载量检测不到与完全依从相关，P值<10%（P = 0.098）。与完全依从的儿童相比，依从性不完全的儿童年龄明显更大，且更有可能服用依非韦伦。这些发现强调了在艾滋病护理机构中定期评估和支持儿童治疗依从性的必要性。
