Calford Michael B, Chino Yuzo M, Das Aniruddha, Eysel Ulf T, Gilbert Charles D, Heinen Stephen J, Kaas Jon H, Ullman Shimon
School of Biomedical Sciences, The University of Newcastle, New South Wales 2308, Australia.
Nature. 2005 Nov 10;438(7065):E3; discussion E3-4. doi: 10.1038/nature04359.
Any analysis of plastic reorganization at a neuronal locus needs a veridical measure of changes in the functional output--that is, spiking responses of the neurons in question. In a study of the effect of retinal lesions on adult primary visual cortex (V1), Smirnakis et al. propose that there is no cortical reorganization. Their results are based, however, on BOLD (blood-oxygen-level-dependent) fMRI (functional magnetic resonance imaging), which provides an unreliable gauge of spiking activity. We therefore question their criterion for lack of plasticity, particularly in the light of the large body of earlier work that demonstrates cortical plasticity.
对神经元位点的可塑性重组进行任何分析，都需要对功能输出的变化进行准确测量——也就是说，要测量相关神经元的放电反应。在一项关于视网膜损伤对成年初级视觉皮层（V1）影响的研究中，斯米尔纳基斯等人提出不存在皮层重组。然而，他们的结果是基于血氧水平依赖性功能磁共振成像（BOLD-fMRI），而这并不能可靠地衡量神经元的放电活动。因此，我们对他们关于缺乏可塑性的判断标准表示质疑，特别是鉴于此前已有大量研究表明存在皮层可塑性。
