[Apolipoprotein B100 as a risk factor of acute coronary syndrome and this risk factor effect on arterial hypertension in patients with ischemic heart disease].

AIM

To clarify correlations between an elevated concentration of apolipoprotein B100 (apoB) in blood plasma and risk of acute coronary syndrome (ACS); to study apoB level in hypertensive patients and its correlation with ischemic heart disease (IHD) risk in these patients.

MATERIAL AND METHODS

Lipid serum spectrum (cholesterol, triglycerides (TG), lipoprotein a (Lpa) and apoB was studied in 456 patients with ACS by NYHA criteria, 119 patients with chronic IHD and 86 patients free of cardiovascular diseases (controls). All 575 patients with IHD were divided into those with and without hypertension (426 and 149 patients, respectively).

RESULTS

Lpa was significantly higher in patients with ACS; apoB was higher in ACS and chronic IHD patients. ApoB was higher in IHD normotensive patients than in controls and higher in IHD hypertensive patients than in IHD normotensive patients and in the control group. Lpa in IHD hypertensive patients was significantly higher (p < 0.045) than in the controls as well as TG (p < 0.05). By the other parameters the groups did not differ.

CONCLUSION

The blood plasma level of apoB higher than 130 mg/dl is an independent and significant risk factor of ACS in IHD patients especially at the age under 60. The level of apoB over 115 mg/dl is a significant risk factor of IHD. The significance of this lipid factor rises in concomitant hypertension.