Kodounis A, Stamboulis E, Constantinidis T S, Liolios A
251 General Airforce Hospital of Athens, Aeginition University of Neurology Hospital, 401 General Army Hospital of Athens, Athens, Greece.
Acta Neurol Scand. 2005 Dec;112(6):403-8. doi: 10.1111/j.1600-0404.2005.00446.x.
Patients with definite multiple sclerosis (MS) were tested for autonomic nervous system (ANS) dysfunction using clinical symptomatology criteria and non-invasive laboratory testing. Exactly 45.45% of patients exhibited subjective symptoms of autonomic dysfunction and 42.42% of patients had abnormal laboratory tests results.
The sympathetic ANS tests were abnormal in 30.3% of MS patients and the parasympathetic ANS tests were abnormal in 18.18% of MS patients. The most sensitive test for the presence of autonomic dysfunction was the sympathetic skin response.
Autonomic dysfunction was often subclinical and we conclude that it is preferable to combine several tests for a more thorough and accurate evaluation of the ANS impairment in MS.
使用临床症状标准和非侵入性实验室检测方法，对明确患有多发性硬化症（MS）的患者进行自主神经系统（ANS）功能障碍检测。确切地说，45.45%的患者表现出自主神经功能障碍的主观症状，42.42%的患者实验室检测结果异常。
30.3%的MS患者交感神经ANS检测异常，18.18%的MS患者副交感神经ANS检测异常。自主神经功能障碍最敏感的检测方法是交感皮肤反应。
自主神经功能障碍通常是亚临床的，我们得出结论，最好结合多种检测方法，以便更全面、准确地评估MS患者的ANS损伤。
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