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低剂量顺铂和5-氟尿嘧啶肝动脉灌注化疗治疗肝转移瘤的临床研究

[A clinical study of hepatic arterial infusion chemotherapy with low-dose CDDP and 5-FU for liver metastases].

作者信息

Yonemitsu Koichiro, Sugihara Shigenori, Toyama Eiichiro, Tsuruta Yutaka, Teshima Kenichi, Tanaka Mutsuo

机构信息

Dept. of Gastroenterological Surgery, Shimonoseki Welfare Social Hospital.

出版信息

Gan To Kagaku Ryoho. 2005 Nov;32(12):1963-6.

Abstract

We followed patients who underwent hepatic arterial infusion chemotherapy with low-dose CDDP+5-FU for liver metastases from colorectal cancer in the outpatient setting. A catheter was inserted from the femoral artery into the proper hepatic artery using the interventional technique. Two complete response (CR) and seven partial response (PR) were achieved, but later 2 of these patients had lung metastases. We conclude that this therapy may be effective, but control of extrahepatic lesions is necessary for life prolongation.

摘要

我们在门诊环境中对接受低剂量顺铂+5-氟尿嘧啶肝动脉灌注化疗的结直肠癌肝转移患者进行了随访。采用介入技术经股动脉将导管插入肝固有动脉。获得了2例完全缓解(CR)和7例部分缓解(PR),但后来这些患者中有2例发生了肺转移。我们得出结论,这种治疗可能有效,但为了延长生命,控制肝外病变是必要的。

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