Moriwaka F, Tashiro K, Itoh K, Hamada T, Miyasaka K
Department of Neurology, Hokkaido University School of Medicine.
Rinsho Shinkeigaku. 1992 Jan;32(1):8-12.
The width of substantia nigra (SN) in 59 cases with idiopathic Parkinson's disease as well as 21 normal controls was analyzed by T2 weighted image (T2WI) of 1.5 Tesla high-field magnetic resonance image (MRI). All patients and controls underwent MRI with the spin-echo sequences used TR/TE: 3000/30 (short TE), and TR/TE:3000/80 (long TE), in 5-mm-thick volumes. The width between the red nucleus and the cerebral peduncle showing low signal intensity areas was measured as that of SN and its ratio to the distance from the aqueduct to the midline of the cerebral peduncle was also measured. The calculated values of the width of SN and its ratio were analyzed by Mann-Whitney test. The significant reduction in the width of SN and its ratio in Parkinson's disease were disclosed as below; the mean calculated values of the width of SN were 2.95 +/- 0.51 mm in controls, 2.68 +/- 0.99 mm in Parkinson's diseases on long TE images (P less than 0.01), and the mean ratio of the width of SN were 13.58 +/- 4.21% in controls, 10.52 +/- 3.07% in Parkinson's diseases on long TE images (P = 0.0002). The narrowing of SN in Parkinson's disease was more prominent in men, and advanced cases with Yahr stage III and IV. Considering that the pars reticulata, which is normally containing iron, shows low signal intensity on long TE images, the width of pars compacta could be measured more precisely on this sequences. The evaluation of the ratio of SN in midbrain on long TE images seemed to be more sensitive than the calculated values in detecting the narrowing of SN and pars compacta in Parkinson's disease.
采用1.5特斯拉高场磁共振成像（MRI）的T2加权像（T2WI）分析59例特发性帕金森病患者及21名正常对照者黑质（SN）的宽度。所有患者及对照者均采用自旋回波序列进行MRI检查，重复时间（TR）/回波时间（TE）分别为：3000/30（短TE）和3000/80（长TE），层厚5毫米。测量红核与显示低信号强度区的大脑脚之间的宽度作为SN的宽度，并测量其与导水管至大脑脚中线距离的比值。SN宽度及其比值的计算值采用Mann-Whitney检验进行分析。结果显示帕金森病患者SN宽度及其比值显著降低；对照组SN宽度的平均计算值为2.95±0.51毫米，帕金森病患者长TE图像上为2.68±0.99毫米（P<0.01），对照组SN宽度的平均比值为13.58±4.21%，帕金森病患者长TE图像上为10.52±3.07%（P=0.0002）。帕金森病患者SN变窄在男性、Yahr分期为III期和IV期的晚期病例中更为明显。鉴于正常含铁的网状部在长TE图像上显示低信号强度，在此序列上可更精确地测量致密部的宽度。在检测帕金森病患者SN和致密部变窄方面，长TE图像上中脑SN比值的评估似乎比计算值更敏感。
