妊娠11 + 0至13 + 6周时全前脑胎儿的额缝。

Metopic suture in fetuses with holoprosencephaly at 11 + 0 to 13 + 6 weeks of gestation.

作者信息

Faro C, Wegrzyn P, Benoit B, Chaoui R, Nicolaides K H

机构信息

Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK.

出版信息

Ultrasound Obstet Gynecol. 2006 Feb;27(2):162-6. doi: 10.1002/uog.2632.

DOI:10.1002/uog.2632

PMID:16285016

Abstract

OBJECTIVE

To investigate the development of the metopic suture in fetuses with holoprosencephaly at 11 + 0 to 13 + 6 weeks of gestation.

METHODS

Three-dimensional (3D) ultrasound was used to measure the height and gap between the frontal bones in 200 normal fetuses and in nine fetuses with holoprosencephaly at 11 + 0 to 13 + 6 (median, 12) weeks of gestation.

RESULTS

In the 200 normal fetuses, the height of the frontal bones increased significantly with gestation from a mean of 2.5 mm (5(th) and 95(th) centiles: 1.9 mm and 3.3 mm) at 11 weeks to 6.1 mm (5(th) and 95(th) centiles: 4.6 mm and 8.1 mm) at 13 + 6 weeks. The gap between the two frontal bones did not change significantly with gestation (mean: 1.5 mm; 5(th) centile: 1.0 mm; 95(th) centile: 2.0 mm). In fetuses with holoprosencephaly, the height of the frontal bones was significantly larger (mean difference, 5.6 SDs; range, 3.9-7.7 SDs; P < 0.0001) and the gap was significantly smaller (mean 0.2 mm, range 0-0.8 mm; P < 0.0001) than those in normal fetuses.

CONCLUSIONS

Holoprosencephaly is associated with an accelerated development of the frontal bones and premature closure of the metopic suture.

摘要

目的

研究孕11 + 0至13 + 6周全前脑畸形胎儿的额缝发育情况。

方法

采用三维超声测量200例正常胎儿以及9例孕11 + 0至13 + 6周（中位数为12周）全前脑畸形胎儿的额骨高度及额骨间缝隙。

结果

在200例正常胎儿中，额骨高度随孕周显著增加，从孕11周时的平均2.5毫米（第5和第95百分位数：1.9毫米和3.3毫米）增至孕13 + 6周时的6.1毫米（第5和第95百分位数：4.6毫米和8.1毫米）。两块额骨之间的缝隙随孕周无显著变化（平均：1.5毫米；第5百分位数：1.0毫米；第95百分位数：2.0毫米）。在全前脑畸形胎儿中，额骨高度显著更大（平均差异5.6个标准差；范围3.9 - 7.7个标准差；P < 0.0001），缝隙显著更小（平均0.2毫米，范围0 - 0.8毫米；P < 0.0001），与正常胎儿相比。