妊娠类天疱疮：免疫吸附治疗
Pemphigoid gestationis: treatment with immunoapheresis.
作者信息
Wöhrl Stefan, Geusau Alexandra, Karlhofer Franz, Derfler Kurt, Stingl Georg, Zillikens Detlef
机构信息
Division of Immunology, Allergy and Infectious Diseases (DIAID), Department of Dermatology, University of Vienna Medical School (AKH Wien), Austria.
出版信息
J Dtsch Dermatol Ges. 2003 Feb;1(2):126-30. doi: 10.1046/j.1610-0387.2003.t01-1-03509.x.
BACKGROUND
Pemphigoid (herpes) gestationis is a rare blistering disease of pregnancy. Topical and systemic corticosteroids and antihistamines are usually sufficient for treatment.
CASE REPORT
A patient suffering from severe, therapy-resistant pemphigoid gestationis was successfully treated with the additional use of six sessions of immunoapheresis. Systemic corticosteroids could be tapered and serum autoantibody levels to bullous pemphigoid antigen 2 (BPAG2 = BP180) significantly dropped during this treatment.
CONCLUSION
Immunoapheresis represents a helpful therapeutic option with few side effects for severe cases of pemphigoid gestationis, unresponsive to conventional treatment.
背景
妊娠类天疱疮（疱疹样）是一种罕见的妊娠水疱性疾病。局部和全身使用皮质类固醇及抗组胺药通常足以进行治疗。
病例报告
一名患有严重、治疗抵抗性妊娠类天疱疮的患者通过额外进行六次免疫吸附治疗而成功治愈。在此治疗期间，全身皮质类固醇用量可逐渐减少，且针对大疱性类天疱疮抗原2（BPAG2 = BP180）的血清自身抗体水平显著下降。
结论
对于常规治疗无反应的严重妊娠类天疱疮病例，免疫吸附是一种副作用少且有益的治疗选择。
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