1型糖尿病患者血浆心房钠尿肽和脑钠尿肽浓度升高。

Elevated plasma concentrations of atrial and brain natriuretic peptide in type 1 diabetic subjects.

作者信息

McKenna K, Smith D, Sherlock M, Moore K, O'Brien E, Tormey W, Thompson C J

机构信息

Dept of Diabetes, Beaumont Hospital, Dublin 9.

出版信息

Ir J Med Sci. 2005 Jul-Sep;174(3):53-7. doi: 10.1007/BF03169149.

DOI:10.1007/BF03169149

PMID:16285340

Abstract

BACKGROUND

The intravenous infusion of atrial (ANP) and brain (BNP) natriuretic peptides have been shown to increase urinary albumin excretion in type 1 diabetes.

AIMS

To measure plasma ANP and BNP concentrations in patients with type 1 diabetes and to examine the parameters associated with elevated plasma concentrations. Methods We measured plasma ANP and BNP concentrations, UAER, HbA1C systolic blood pressure, and left ventricular mass index. Plasma ANP and BNP were also measured in non-diabetic control subjects for comparison.

RESULTS

Using multivariate regression analysis plasma ANP correlated positively with HbA1C (1.9 + 0.47, p = 0.0002), UAER (0.37 + 0.05, p = 0.00001), SBP (1.26 + 0.5, p = 0.01) and LVMI (00.46 + 0.25, p = 0.07). BNP was positively related with LVMI (0.95 + 0.4, p = 0.02), and UAER (0.56 + 0.08, p = 0.001).

CONCLUSIONS

Plasma concentrations of ANP and BNP are elevated in some patients with type 1 diabetes. Plasma ANP concentrations are closely related to UAER and elevated plasma concentrations are associated with poor glycaemic control and systemic hypertension. Plasma BNP concentration is related to LVMI.

摘要

背景

已证明静脉输注心房利钠肽（ANP）和脑利钠肽（BNP）可增加1型糖尿病患者的尿白蛋白排泄。

目的

测定1型糖尿病患者血浆ANP和BNP浓度，并检查与血浆浓度升高相关的参数。方法我们测定了血浆ANP和BNP浓度、尿白蛋白排泄率（UAER）、糖化血红蛋白（HbA1C）、收缩压和左心室质量指数。还在非糖尿病对照受试者中测定了血浆ANP和BNP以作比较。

结果

使用多变量回归分析，血浆ANP与HbA1C（1.9 + 0.47，p = 0.0002）、UAER（0.37 + 0.05，p = 0.00001）、收缩压（SBP，1.26 + 0.5，p = 0.01）和左心室质量指数（LVMI，00.46 + 0.25，p = 0.07）呈正相关。BNP与LVMI（0.95 + 0.4，p = 0.02）和UAER（0.56 + 0.08，p = 0.001）呈正相关。